As to the first question, yes, it's possible. Humans worked much harder metals by hand and still do to this day (you can do an lot of high quality work with just a straight edge, a saw and a file), but a few low-cost power tools make the job a lot easier.
If you have (access to) a Dremel or other rotary tool, the Roto-Zip
cutters work well on plastic. I haven't used the actual Dremel
equivalent but I imagine it does as good a job. They will also work on aluminum.
If you only have hand tools, it gets a little more time consuming, but really not that much more. You can use a
coping saw to make all manners of slots and circles in plastic enclosures. It also works with aluminum, but is a little harder (and much noisier) and the blades will dull faster. An X-Acto knife is useful for cleaning up the rough edges.
If you're going to be doing this kind of thing a lot, you really should have at least minimal power tools and learn to use them. You don't need professional grade stuff, search eBay for cheap rotary tool sets and you'll probably find something quite usable for under $20.